John H Hutchinson Selected Research

5-Lipoxygenase-Activating Protein Inhibitors

11/2009	A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye.
2/2008	What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.

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John H Hutchinson Research Topics

Disease

7	Inflammation (Inflammations) 01/2017 - 11/2009
5	Allergic Rhinitis 11/2011 - 02/2008
5	Asthma (Bronchial Asthma) 07/2011 - 02/2008
3	Pneumonia (Pneumonitis) 07/2011 - 12/2009
2	Schizophrenia (Dementia Praecox) 09/2005 - 03/2005
1	Neoplasm Metastasis (Metastasis) 01/2022
1	Leukemia 01/2022
1	Neoplasms (Cancer) 01/2022
1	Fibrosis (Cirrhosis) 01/2017
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017
1	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 01/2012
1	Atopic Dermatitis (Atopic Eczema) 07/2011
1	Rhinorrhea 07/2010
1	Sneezing 07/2010
1	Pruritus (Itching) 07/2010
1	Metaplasia 03/2010
1	Airway Remodeling 03/2010
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2010
1	Hyperplasia 03/2010
1	Shock 12/2009
1	Eye Diseases (Eye Disease) 11/2009
1	Hypersensitivity (Allergy) 11/2009
1	Atherosclerosis 02/2008
1	Myocardial Infarction 02/2008
1	Stroke (Strokes) 02/2008
1	Osteoporosis 09/2004

Drug/Important Bio-Agent (IBA)

3	AllergensIBA 01/2012 - 10/2009
3	prostaglandin D2 receptorIBA 11/2011 - 08/2009
3	OvalbuminIBA 07/2011 - 10/2009
3	5-Lipoxygenase-Activating ProteinsIBA 12/2009 - 10/2009
2	Pharmaceutical PreparationsIBA 01/2022 - 02/2008
2	Prostaglandins DIBA 07/2011 - 07/2010
2	ProstaglandinsIBA 07/2011 - 07/2010
2	propionic acid (potassium propionate)IBA 08/2010 - 12/2009
2	ZymosanIBA 08/2010 - 12/2009
2	Blood Proteins (Serum Proteins)IBA 08/2010 - 12/2009
2	LeukotrienesIBA 11/2009 - 02/2008
2	5-Lipoxygenase-Activating Protein InhibitorsIBA 11/2009 - 02/2008
2	metabotropic glutamate receptor 2IBA 09/2005 - 03/2005
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 01/2022
1	NexusIBA 01/2022
1	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 01/2022
1	Tyrosine Kinase InhibitorsIBA 01/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2022
1	Monomeric GTP-Binding ProteinsIBA 01/2022
1	Protein Tyrosine PhosphatasesIBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 01/2022
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2022
1	Choline (Choline Chloride)IBA 01/2017
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2017
1	Nasal Decongestants (Decongestants)IBA 01/2012
1	Interleukin-4 (Interleukin 4)IBA 01/2012
1	Histamine Antagonists (Antihistamines)IBA 01/2012
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2012
1	biphenylylacetic acid (felbinac)IBA 11/2011
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 07/2011
1	Leukotriene B4IBA 08/2010
1	Proteins (Proteins, Gene)FDA Link 08/2010
1	Lipoxygenase (Lipoxygenase-1)IBA 08/2010
1	Thromboxane Receptors (Thromboxane Receptor)IBA 07/2010
1	ramatrobanIBA 07/2010
1	SmokeIBA 03/2010
1	Interleukin-5 (Interleukin 5)IBA 12/2009
1	3- (3- tert- butylsulfanyl- 1- (4- (6- methoxypyridin- 3- yl)benzyl)- 5- (pyridin- 2- ylmethoxy)- 1H- indol- 2- yl)- 2,2- dimethylpropionic acidIBA 12/2009
1	Eosinophil PeroxidaseIBA 12/2009
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 11/2009
1	Arachidonic Acid (Vitamin F)IBA 11/2009
1	indoleIBA 09/2005
1	IndansIBA 03/2005

Therapy/Procedure

3	Therapeutics 01/2022 - 03/2010
2	Oral Administration 01/2017 - 09/2004